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|Title: ||Risk factor stratification of peripheral arterial disease in the United Kingdom|
|Authors: ||Khan, Shaukat Nawaz|
|Issue Date: ||2005 |
|Publisher: ||Newcastle University|
|Abstract: ||Objective: To document the patient characteristics, primary care and hospital
management and QoL in patients with intermittent claudication in the United
Kingdom. Also to determine the appropriate use of prophylactic therapy, to
determine markers of high and low risk and to suggest approaches to optimise
the management of peripheral arterial disease.
Methods: 474 patients were recruited from 23 centres across the United
Kingdom. Data was collected at baseline and at six months and risk factors
profile was analysed.
Results: Symptomatic disease is more prevalent in men and those above 60. A
high proportion of patients were hypertensive and control of blood pressure was
not optimal. Use of antiplatelet agents and lipid lowering therapy was less than
satisfactory though it improved following hospital referral. Life style modification
advice was patchy and not uniform and intensive support for such programmes
was lacking. Majority of patients improved not only on clinical parameters but
also their QoL over a six month period. 35% underwent peripheral imaging and
7.8% had an interventional procedure. 14% had a vascular event over six
months. Low ABPI, high systolic pressure and prior CHD were significantly
associated with development of all vascular events.
Conclusions: Use of appropriate therapy to reduce the risk factor profile is less
than optimal. There is a need for uniform national guidelines for appropriate
management of peripheral arterial disease patients in the United Kingdom.|
|Description: ||MD Thesis|
|Appears in Collections:||School of Medical Sciences Education Development|
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